The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, and its functions include attaching chromatin domains to the nuclear periphery and localizing some ...

Lamins are members of the intermediate filament (IF) superfamily and are classified as type V IFs. However, the structure of lamin genes indicates that they were possibly the evolutionary pregenitors ...

Children with Hutchinson-Gilford Progeria Syndrome (HGPS) race through life against an unfairly fast clock. By 6-18 months of age, they show signs of premature aging including hair loss, stiff joints, ...

A tremendous amount of genetic material must be packed into the nucleus of every cell--a tiny compartment. One of the biggest challenges in biology is to understand how certain regions of this highly ...

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the ...

In a study with lab-grown mouse cells, Johns Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell’s “command center” — its ...

Hundreds of diseases are associated with a flaw in the LMNA gene, and researchers at Alfaisal University in Saudi Arabia are picking apart its behaviour to diagnose some of the most serious conditions ...