Mucin concentrations are abnormally raised in each of the four muco-obstructive diseases — COPD, cystic fibrosis, primary ciliary dyskinesia, and non–cystic fibrosis bronchiectasis — and these ...

Charles Burger, MD: Pulmonary hypertension really refers to a state where the right heart is generating high pressures to circulate the blood through the lung. Pulmonary arterial hypertension is a ...

Erdosteine is a multimechanism, mucolytic agent that decreases the sputum viscoelastic properties and bacterial adhesion to the cell membrane, endowed with bronchial anti-inflammatory activity and a ...

"Taken together the interplay of sex-specific gene regulation and its impact on ECM-related genes, influenced by factors such as genetics, epigenetics, environmental exposures, steroid hormones, aging ...

Alterations in metabolism of lipids, amino acids, glucose, nucleotides, and pulmonary and gut microbiome play a crucial role in COPD development. These metabolites have great potential as early ...

—Investigators from the U.S. and U.K have identified neutrophil elastase (NE) and its inhibitor elafin as possible biomarkers in the pathogenesis of pulmonary arterial hypertension (PAH). “An ...

Current therapies for chronic obstructive pulmonary disease (COPD) alleviate symptoms, but do not deal with disease progression. Respiratory mucus is primarily made up of mucins, of which mucin 5AC ...

Further investigation on the pathogenesis and treatment of patients with schistosome-associated pulmonary arterial hypertension (Sch-PAH) may lead to improved symptoms and higher rates of survival. A ...

The Pulmonary, Critical Care, and Sleep Medicine Section has strong nationally recognized research programs in lung diseases and critical care medicine. The faculty performs a broad spectrum of ...

Researchers at Weill Cornell Medicine and New York-Presbyterian in New York have discovered that injecting mice with healthy pulmonary endothelial cells (ECs)—the cells that line the walls of blood ...