Their approach combined two levels of data: interactions between single zinc fingers and DNA, and between each zinc finger and its neighbouring finger. These zinc finger pair interactions influence ...

Zinc is “the Barry Manilow of heavy metals—really dull and really boring. It’s not fancy, like iron or copper.” But as Adrian Woolfson, BM BCh PhD, reaches his first-year anniversary as Sangamo’s ...

Novartis is the latest big drug firm to strike a collaboration with Sangamo Therapeutics. The two firms will develop therapies based on Sangamo’s zinc finger technology that targets genes linked to ...

Researchers are using minute, naturally occurring proteins called zinc fingers to engineer T-cells to one day treat AIDS in humans. Using the zinc fingers, scientists have shown that they could reduce ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from the Institute of Science, Tokyo, Japan.

Sangamo Therapeutics researchers illustrated the linkers and architectures they developed in a study published today in Nature Communications. The study detailed the latest improvements incorporated ...

Figure 2: Compilation of α-helix amino acid sequences of selected zinc fingers. Figure 4: Selected zinc finger peptide binding to RRE-IIB RNA in vivo. RRE-IIB (nucleotides 39–81 of HIV RRE with 5' GGG ...

Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

There are a lot of unknowns when it comes to the way Alzheimer's takes hold in the brain, but one area where researchers are focusing much of their attention is the development of toxic clumps of ...

If you're an investor who's heard of zinc-finger proteins and gene editing but you aren't sure what it all means, this can help answer your questions. There are 350 million people worldwide with rare ...

Researchers have, for the first time, modified a single, disease-causing mutation without altering any other parts of the genome in human stem cells. Scientists in Rudolph Jaenisch’s lab at the ...